Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex

XY Choo; LE McInnes; A Grubman; JM Wasielewska; I Belaya; E Burrows; H Quek; JC Martín; S Loppi; A Sorvari; D Rait; A Powell; C Duncan; JR Liddell; H Tanila; JM Polo; T Malm; KM Kanninen; PS Donnelly; AR White

Journal article

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex

XY Choo, LE McInnes, A Grubman, JM Wasielewska, I Belaya, E Burrows, H Quek, JC Martín, S Loppi, A Sorvari, D Rait, A Powell, C Duncan, JR Liddell, H Tanila, JM Polo, T Malm, KM Kanninen, PS Donnelly, AR White

International Journal of Molecular Sciences | Published : 2022

DOI: 10.3390/ijms231810722

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Abstract

Neuroinflammation has a major role in several brain disorders including Alzheimer’s disease (AD), yet at present there are no effective anti-neuroinflammatory therapeutics available. Copper(II) complexes of bis(thiosemicarbazones) (CuII(gtsm) and CuII(atsm)) have broad therapeutic actions in preclinical models of neurodegeneration, with CuII(atsm) demonstrating beneficial outcomes on neuroinflammatory markers in vitro and in vivo. These findings suggest that copper(II) complexes could be harnessed as a new approach to modulate immune function in neurodegenerative diseases. In this study, we examined the anti-neuroinflammatory action of several low-molecular-weight, charge-neutral and lipophi..

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University of Melbourne Researchers

Jeffrey Liddell Author

Paul Donnelly Author

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Awarded by University of Queensland

Funding Acknowledgements

This research was funded by the National Health and Medical Research Council of Australia (NHMRC) GNT0628946, and GNT1118452, and the Australian Research Council, (ARC) DP150100649, DP160100288, DP200100178 and the APC was funded by The University of Queensland.